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Article

A complex containing the CPSF73 endonuclease and other polyadenylation factors associates with U7 snRNP and is recruited to histone pre-mRNA for 3'-end processing.

Molecular and cellular biology - 1 Jan 2013

Yang Xiao-Cui, Sabath Ivan, Dębski Jan, Kaus-Drobek Magdalena, Dadlez Michał, Marzluff William F, Dominski Zbigniew

Abstract excerpt

Animal replication-dependent histone pre-mRNAs are processed at the 3' end by endonucleolytic cleavage that is not followed by polyadenylation. The cleavage reaction is catalyzed by CPSF73 and depends on the U7 snRNP and its integral component, Lsm11. A critical role is also played by the 220-kDa protein FLASH, which interacts with Lsm11. Here we demonstrate that the N-terminal regions of these two proteins form...

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Identifiers

PMID: 23071092
DOI: 10.1128/MCB.00653-12
PMCID: PMC3536302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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