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Article

The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3'-end processing of animal histone mRNAs.

Nucleic acids research - 1 Nov 2010

Ruepp Marc-David, Vivarelli Silvia, Pillai Ramesh S, Kleinschmidt Nicole, Azzouz Teldja N, Barabino Silvia M L, Schümperli Daniel

Abstract excerpt

Metazoan replication-dependent histone pre-mRNAs undergo a unique 3'-cleavage reaction which does not result in mRNA polyadenylation. Although the cleavage site is defined by histone-specific factors (hairpin binding protein, a 100-kDa zinc-finger protein and the U7 snRNP), a large complex consisting of cleavage/polyadenylation specificity factor, two subunits of cleavage stimulation factor and symplekin acts as...

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Identifiers

PMID: 20634199
DOI: 10.1093/nar/gkq613
PMCID: PMC2995043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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