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Article

Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in recognition of 3'-end processing signals.

Nucleic acids research - 25 Jan 2018

Yang Wen, Hsu Peter L, Yang Fan, Song Jae-Eun, Varani Gabriele

Abstract excerpt

Cleavage stimulation factor (CstF) is a highly conserved protein complex composed of three subunits that recognizes G/U-rich sequences downstream of the polyadenylation signal of eukaryotic mRNAs. While CstF has been identified over 25 years ago, the architecture and contribution of each subunit to RNA recognition have not been fully understood. In this study, we provide a structural basis for the recruitment of...

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Identifiers

PMID: 29186539
DOI: 10.1093/nar/gkx1177
PMCID: PMC5778602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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