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Article

Structural Insights into the Human Pre-mRNA 3'-End Processing Machinery.

Molecular cell - 20 Feb 2020

Zhang Yixiao, Sun Yadong, Shi Yongsheng, Walz Thomas, Tong Liang

Abstract excerpt

The mammalian pre-mRNA 3'-end-processing machinery consists of cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), and other proteins, but the overall architecture of this machinery remains unclear. CPSF contains two functionally distinct modules: a cleavage factor (mCF) and a polyadenylation specificity factor (mPSF). Here, we have produced recombinant human CPSF and CstF...

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Identifiers

PMID: 31810758
DOI: 10.1016/j.molcel.2019.11.005
PMCID: PMC7036032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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