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Article

Composite SMG5-SMG6 PIN domain formation is essential for NMD.

Nature communications - 19 Feb 2026

Kurscheidt Katharina, Theunissen Sophie, Pasquali Natalia, Becker Kerstin, Boehm Volker, Conti Elena, Gehring Niels H

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) relies on the coordinated assembly and action of multiple protein factors. Degradation of target mRNAs begins with endonucleolytic cleavage near premature stop codons, but the mechanisms of endonuclease activation and regulation remain unclear. Using structural predictions, biochemical in vitro assays, and cell-based NMD analysis, we show that SMG5 and SMG6 interact via their...

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Identifiers

PMID: 41714610
DOI: 10.1038/s41467-026-69819-w
PMCID: PMC12923823

Genes

SMG5
SMG6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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Composite SMG5-SMG6 PIN domain formation is essential for NMD.PMID 41714610Read ↗

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