Article

Single-Cell Transcriptomic Signatures Enable Stratified Combination Therapy for Platinum-Resistant Ovarian Cancer

2026-03-06

Abstract excerpt

In high-grade serous carcinoma (HGSC), extensive intra-tumoral heterogeneity hinders complete eradication and remains a major obstacle to developing combination therapies capable of eliminating subpopulations resistant to standard-of-care treatment. Using single-cell RNA sequencing of 72 samples from 54 HGSC patients spanning treatment-naïve, post-neoadjuvant chemotherapy and relapse stages, we established a carbo...

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Literature Corpus work: 9294bdf9-275e-5df6-8ee5-529178c3b0c2
DOI: 10.64898/2026.03.04.709546

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