Article

Deconvolution of Cell Type-Specific Drug Responses in Human Tumor Tissue with Single-Cell RNA-seq

2020-04-24

Abstract excerpt

Precision oncology requires the timely selection of effective drugs for individual patients. An ideal platform would enable rapid screening of cell type-specific drug sensitivities directly in patient tumor tissue and reveal strategies to overcome intratumoral heterogeneity. Here we combine multiplexed drug perturbation in acute slice culture from freshly resected tumors with single-cell RNA sequencing (scRNA-seq)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8de42798-f13d-54aa-b540-546ff8ce774b
DOI: 10.1101/2020.04.22.056341

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deconvolution of Cell Type-Specific Drug Responses in Human Tumor Tissue with Single-Cell RNA-seqDOI 10.1101/2020.04.22.056341Read

Deconvolution of cell type-specific drug responses in human tumor tissue with single-cell RNA-seqSemantic proximity Read

Integration of Pan-Cancer Cell Line and Single-Cell Transcriptomic Profiles Enables Inference of Therapeutic Vulnerabilities in Heterogeneous TumorsSemantic proximity Read

A single-cell atlas linking intratumoral states to therapeutic vulnerabilities across cancersSemantic proximity Read

Single-Cell Transcriptomics Sheds Light on Tumor Evolution: Perspectives from City of Hope’s Clinical Trial TeamsSemantic proximity Read

Inferring therapeutic vulnerability within tumors through integration of pan-cancer cell line and single-cell transcriptomic profilesSemantic proximity Read

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma.Semantic proximity Read

Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastomaSemantic proximity Read

Predicting drug response from single-cell expression profiles of tumoursSemantic proximity Read

Single-Cell Transcriptomic Signatures Enable Stratified Combination Therapy for Platinum-Resistant Ovarian CancerSemantic proximity Read

COMPARISON OF HIGH-THROUGHPUT SINGLE-CELL RNA-SEQ METHODS FOR EX VIVO DRUG SCREENINGSemantic proximity Read

Trellis Single-Cell Screening Reveals Stromal Regulation of Patient-Derived Organoid Drug ResponsesSemantic proximity Read

scPharm: identifying pharmacological subpopulations of single cells for precision medicine in cancersSemantic proximity Read