Article

Trellis Single-Cell Screening Reveals Stromal Regulation of Patient-Derived Organoid Drug Responses

2022-10-21

Abstract excerpt

Patient-derived organoids (PDOs) can model personalized therapy responses, however current screening technologies cannot reveal drug response mechanisms or study how tumor microenvironment cells alter therapeutic performance. To address this, we developed a highly-multiplexed mass cytometry platform to measure post translational modification (PTM) signaling in >2,500 colorectal cancer (CRC) PDOs and cancer-associa...

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Literature Corpus work: 46fc12f2-5569-5132-9ff6-c9ee69ca8121
DOI: 10.1101/2022.10.19.512668

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