Article
Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer.
Nature communications - 24 May 2021
Nath Aritro, Cosgrove Patrick A, Mirsafian Hoda, Christie Elizabeth L, Pflieger Lance, Copeland Benjamin, Majumdar Sumana, Cristea Mihaela C, Han Ernest S, Lee Stephen J, Wang Edward W, Fereday Sian, Traficante Nadia, Salgia Ravi, Werner Theresa, Cohen Adam L, Moos Philip, Chang Jeffrey T, Bowtell David D L, Bild Andrea H
Abstract excerpt
The evolution of resistance in high-grade serous ovarian cancer (HGSOC) cells following chemotherapy is only partially understood. To understand the selection of factors driving heterogeneity before and through adaptation to treatment, we profile single-cell RNA-sequencing (scRNA-seq) transcriptomes of HGSOC tumors collected longitudinally during therapy. We analyze scRNA-seq data from two independent patient...
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