Article

Molecular Profiling and High-Content Drug Screening of Metastatic Colorectal Cancer Organoids Reveal Evolutionary Mechanisms of Pan-KRAS Inhibitor Resistance

2026-01-14

Abstract excerpt

Metastatic colorectal cancer exhibits extensive intertumoral and intratumoral heterogeneity, which underlies variable treatment responses and the inevitable emergence of drug resistance. Preclinical models that accurately reflect this heterogeneity and enable the investigation of resistance mechanisms at the clonal level, while also providing sensitive and quantitative measurements of treatment response, remain li...

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Literature Corpus work: 3c576ef2-7f6d-5661-b460-9910367f723d
DOI: 10.64898/2026.01.14.699345

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