Article

Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer

2021-01-12

Abstract excerpt

The evolution of resistance in high-grade serous ovarian cancer (HGSOC) cells following chemotherapy is only partially understood. To uncover phenotypic changes associated with chemotherapy resistance, we profiled single-cell RNA-sequencing (scRNA-seq) transcriptomes of HGSOC tumors collected longitudinally during patient treatment. Analysis of scRNA-seq data from two independent patient cohorts revealed that HGSO...

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Literature Corpus work: 37e4c65c-fbd1-5f23-a477-c1d3e25e0f6f
DOI: 10.21203/rs.3.rs-141400/v1

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