Article

<i>U2AF1 S34F</i> enhances tumorigenic potential of lung cells by exhibiting synergy with <i>KRAS</i> mutation and altering response to environmental stress

2024-09-15

Abstract excerpt

<h4>ABSTRACT</h4> Although U2AF1 S34F is a recurrent splicing factor mutation in lung adenocarcinoma (ADC), U2AF1 S34F alone is insufficient for producing tumors in previous models. Because lung ADCs with U2AF1 S34F frequently have co-occurring KRAS mutations and smoking histories, we hypothesized that tumor-forming potential arises from U2AF1 S34F interacting with oncogenic KRAS and environmental stres...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 927a7b51-9792-503a-a119-0b29cf400f73
DOI: 10.1101/2024.09.11.612492

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>U2AF1 S34F</i> enhances tumorigenic potential of lung cells by exhibiting synergy with <i>KRAS</i> mutation and altering response to environmental stressDOI 10.1101/2024.09.11.612492Read

Early-stage lung adenocarcinoma is driven by an injury-associated, plastic cell state dependent on a KRAS-ITGA3-SRC axisSemantic proximity Read

U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutationsSemantic proximity Read

Cross-species analysis identifies genotype-driven vulnerabilities in lung adenocarcinomaSemantic proximity Read

Functional significance of U2AF1 S34F mutations in lung adenocarcinomas.Semantic proximity Read

Wild-type U2AF1 antagonizes the splicing program characteristic of U2AF1-mutant tumors and is required for cell survivalSemantic proximity Read

Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.Semantic proximity Read

Integrative Profiling of Alternative Splicing Induced by U2AF1 S34F Mutation in Lung Adenocarcinoma Reveals a Mechanistic Link to Mitotic Stress.Semantic proximity Read

Lineage plasticity of the integrated stress response is a hallmark of cancer evolutionSemantic proximity Read

Mutant U2AF1-induced differential alternative splicing causes an oxidative stress in bone marrow stromal cells.Semantic proximity Read

Tobacco smoke alters the trajectory of lung adenocarcinoma evolution via effects on somatic selection and epistasisSemantic proximity Read

A novel human model to deconvolve cell-intrinsic phenotypes of genetically dysregulated pathways in lung squamous cell carcinomaSemantic proximity Read

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinomaSemantic proximity Read