Article

Early-stage lung adenocarcinoma is driven by an injury-associated, plastic cell state dependent on a KRAS-ITGA3-SRC axis

2024-03-03

Abstract excerpt

Glycine 12 mutations in the GTPase KRAS (KRAS G12 ) are a known initiating event for lung adenocarcinoma (LUAD) with broad clinical relevance. KRAS G12 mutations promote cell-intrinsic rewiring of the lung alveolar type II progenitor (AT2) cells, but to what extent such changes interplay with pathways essential for lung homeostasis and cell fate is unclear. We used single-cell RNA-seq (scRNA-seq) from AT2-mesenc...

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Literature Corpus work: 1b305746-0ce8-5bdd-b61f-57c7661f428e
DOI: 10.1101/2024.02.27.582165

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