Article

Cross-species analysis identifies genotype-driven vulnerabilities in lung adenocarcinoma

2025-08-27

Abstract excerpt

While three major genetic alteration subsets, characterized by mutations in STK11, KRAS , and EGFR , are seminal in driving tumorigenesis in LUAD, their distinct effects on tumor cells and the tumor microenvironment are not fully understood. Here, we map critical oncogenic subset-specific vulnerabilities by identifying conserved cell-type-specific reprogrammings between human and mouse LUAD. Through harmonized s...

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Identifiers and source

Literature Corpus work: 2779187f-f400-58ed-94b3-9ff11bf773a6
DOI: 10.1101/2025.08.24.671070

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