Article

U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations

2025-03-25

Abstract excerpt

The mechanisms by which somatic mutations of splicing factors, such as U2AF1 S34F in lung adenocarcinoma, contribute to cancer pathogenesis are not well understood. Here, we used prime editing to modify the endogenous U2AF1 gene in lung adenocarcinoma cells and assessed the resulting impact on alternative splicing. These analyses identified KRAS as a key target modulated by U2AF1 S34F . One specific KRAS muta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 17ba0b16-ea65-553d-b43f-613eec026766
DOI: 10.1101/2025.03.21.644128

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutationsDOI 10.1101/2025.03.21.644128Read

U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations.Semantic proximity Read

Wild-type U2AF1 antagonizes the splicing program characteristic of U2AF1-mutant tumors and is required for cell survivalSemantic proximity Read

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival.Semantic proximity Read

U2AF1 mutation connects DNA damage to the alternative splicing of RAD51 in lung adenocarcinomas.Semantic proximity Read

A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events.Semantic proximity Read

Nanopore sequencing reveals <i>U2AF1 S34F</i> -associated full-length isoformsSemantic proximity Read

<i>U2AF1 S34F</i> enhances tumorigenic potential of lung cells by exhibiting synergy with <i>KRAS</i> mutation and altering response to environmental stressSemantic proximity Read

Multiplexed identification of RAS paralog imbalance as a driver of lung cancer growthSemantic proximity Read

Functional significance of U2AF1 S34F mutations in lung adenocarcinomas.Semantic proximity Read

Aberrant RNA splicing and therapeutic opportunities in cancers.Semantic proximity Read

Full-length transcript alterations in human bronchial epithelial cells with U2AF1 S34F mutations.Semantic proximity Read

The splicing factor U2AF1 contributes to cancer progression through a non-canonical role in translation regulationSemantic proximity Read