Article

A novel human model to deconvolve cell-intrinsic phenotypes of genetically dysregulated pathways in lung squamous cell carcinoma

2023-12-14

Abstract excerpt

<h4>ABSTRACT</h4> Tractable, patient relevant models are needed to investigate cancer progression and heterogeneity. Here, we report an alternative and unique in vitro model of lung squamous cell carcinoma (LUSC) using primary human bronchial epithelial cells (hBECs) from three healthy donors. The co-operation of ubiquitous alterations ( TP53 and CDKN2A loss) and components of commonly deregulated pathways incl...

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Literature Corpus work: 7eabb932-0920-5cb7-b63c-055a0c1c0436
DOI: 10.1101/2023.12.13.568969

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