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Article

Mutant U2AF1-induced differential alternative splicing causes an oxidative stress in bone marrow stromal cells.

Experimental biology and medicine (Maywood, N.J.) - 1 Aug 2021

Liu Zhe, Dong Xuanjia, Cao Zhijie, Qiu Shaowei, Li Yihui, Zhong Mengjun, Xue Zhenya, Xu Yingxi, Xing Haiyan, Tang Kejing, Tian Zheng, Wang Min, Rao Qing, Wang Jianxiang

Abstract excerpt

Alternative splicing (AS) is a critical regulatory process of gene expression. In bone marrow microenvironment, AS plays a critical role in mesenchymal stem cells fate determination by forming distinct isoforms of important regulators. As a spliceosome factor, U2AF1 is essential for the catalysis of pre-mRNA splicing, and its mutation can cause differential AS events. In the present study, by forced expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34034558
DOI: 10.1177/15353702211010130
PMCID: PMC8719038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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