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Article

Functional significance of U2AF1 S34F mutations in lung adenocarcinomas.

Nature communications - 13 Dec 2019

Esfahani Mohammad S, Lee Luke J, Jeon Young-Jun, Flynn Ryan A, Stehr Henning, Hui Angela B, Ishisoko Noriko, Kildebeck Eric, Newman Aaron M, Bratman Scott V, Porteus Matthew H, Chang Howard Y, Alizadeh Ash A, Diehn Maximilian

Abstract excerpt

The functional role of U2AF1 mutations in lung adenocarcinomas (LUADs) remains incompletely understood. Here, we report a significant co-occurrence of U2AF1 S34F mutations with ROS1 translocations in LUADs. To characterize this interaction, we profiled effects of S34F on the transcriptome-wide distribution of RNA binding and alternative splicing in cells harboring the ROS1 translocation. Compared to its wild-type...

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Identifiers

PMID: 31836708
DOI: 10.1038/s41467-019-13392-y
PMCID: PMC6911043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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