Article

Lineage plasticity of the integrated stress response is a hallmark of cancer evolution

2025-02-13

Abstract excerpt

<h4>ABSTRACT</h4> The link between the “stress phenotype”-a well-established hallmark of cancer-and its role in tumor progression and intratumor heterogeneity remains poorly defined. The integrated stress response (ISR) is a key adaptive pathway that enables tumor survival under oncogenic stress. While ISR has been implicated in promoting tumor growth, its precise role in driving tumor evolution and heterogeneity...

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Literature Corpus work: f0424225-1d5c-5a0a-a915-2619737cebf0
DOI: 10.1101/2025.02.10.637516

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