Article

Tobacco smoke alters the trajectory of lung adenocarcinoma evolution via effects on somatic selection and epistasis

2024-12-02

Abstract excerpt

The mutagenic effects of tobacco smoke are well-reported. However, tobacco smoke also likely alters the somatic selective pressures that drive lung cancer evolution, and these altered pressures have never been quantified nor compared to the oncogenic effects of tobacco-induced mutagenesis. This comparison is necessary for prediction of targeted therapy efficacy given exposure history. Here, we estimated background...

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Identifiers and source

Literature Corpus work: 6df4eaef-4e15-5078-833d-72cd2f804955
DOI: 10.1101/2024.11.27.625765

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