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Article

Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.

The EMBO journal - 1 Jul 2024

Moye Aaron L, Dost Antonella Fm, Ietswaart Robert, Sengupta Shreoshi, Ya VanNashlee, Aluya Chrystal, Fahey Caroline G, Louie Sharon M, Paschini Margherita, Kim Carla F

Abstract excerpt

Glycine-12 mutations in the GTPase KRAS (KRASG12) are an initiating event for development of lung adenocarcinoma (LUAD). KRASG12 mutations promote cell-intrinsic rewiring of alveolar type-II progenitor (AT2) cells, but to what extent such changes interplay with lung homeostasis and cell fate pathways is unclear. Here, we generated single-cell RNA-seq (scRNA-seq) profiles from AT2-mesenchyme organoid co-cultures,...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Proto-Oncogene Proteins p21(ras)

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Source

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Identifiers

PMID: 38755258
DOI: 10.1038/s44318-024-00113-5
PMCID: PMC11251082

Genes

SRC
ITGA3
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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