Article

Small-molecule-based regulation of gene expression in human astrocytes upon both positive and negative actuations of G-quadruplex control systems

2024-02-21

Abstract excerpt

A great deal of attention is currently being paid to strategies aiming at uncovering the biology of the four-stranded nucleic acid structure G-quadruplex (G4) via their stabilization in cells using G4-specific ligands. The conventional definition of chemical biology implies that a complete assessment of G4 biology can only be achieved through the implementation of a complementary approach involving the destabiliza...

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Literature Corpus work: 9277c15b-95ff-5b4b-9f62-196531309327
DOI: 10.1101/2024.02.16.580621

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