Article

Novel regulators of PrP <sup>C</sup> biosynthesis revealed by genome-wide RNA interference

2021-01-28

Abstract excerpt

The cellular prion protein PrP C is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of PrP C may represent therapeutic targets against human prion diseases. Here we performed an arrayed whole-transcriptome RNA interference screen to identify modulators of PrP C expression. We cultured human U251-MG...

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Literature Corpus work: 4d9be433-f7f4-5e97-90f2-5f01a354a160
DOI: 10.1101/2021.01.28.428672

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