Article

G-quadruplexes sequester free heme in living cells

2019-05-28

Abstract excerpt

Heme is an essential cofactor for many enzymes, but free heme is toxic and its levels are tightly regulated. G-quadruplexes bind heme avidly in vitro , raising the possibility that they may sequester heme in vivo . If so, then treatment that displaces heme from quadruplexes is predicted to induce expression of genes involved in iron and heme homeostasis. Here we show that PhenDC3, a G-quadruplex ligand structura...

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Literature Corpus work: 4267d104-15f4-5003-89c7-9f6d56b4318a
DOI: 10.1101/652297

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