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Article

Pathogenic SNPs Affect Both RNA and DNA G-Quadruplexes' Responses to Ligands.

ACS chemical biology - 17 May 2024

Turcotte Marc-Antoine, Perreault Jean-Pierre

Abstract excerpt

Single nucleotide polymorphisms (SNPs) are common genetic variations that are present in over 1% of the population and can significantly modify the structures of both DNA and RNA. G-quadruplex structures (G4) are formed by the superposition of tetrads of guanines. To date, the impact of SNPs on both G4 ligands' binding efficacies and specificities has not been investigated. Here, using a bioinformatically...

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Identifiers

PMID: 38688038
DOI: 10.1021/acschembio.4c00104
PMCID: PMC11106744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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