Article

Effective lowering of α-synuclein expression by targeting G-quadruplex structures within the SNCA gene

2024-02-09

Abstract excerpt

<h4>ABSTRACT</h4> Alpha-synuclein, encoded by the SNCA gene, is a pivotal protein implicated in the pathogenesis of synucleinopathies, including Parkinson’s disease. Current approaches for modulating alpha-synuclein levels involve antisense nucleotides, siRNAs, and small molecules targeting SNCA’s 5’-UTR mRNA. Here, we propose a groundbreaking strategy targeting G-quadruplex structures to effectively modulate SNC...

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Literature Corpus work: ba88c9a4-1426-593d-be76-a87ec833fd0e
DOI: 10.1101/2024.02.09.579657

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