Article
The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules To Downregulate Gene Expression.
Journal of the American Chemical Society - 7 Jun 2017
Brown Robert V, Wang Ting, Chappeta Venkateshwar Reddy, Wu Guanhui, Onel Buket, Chawla Reena, Quijada Hector, Camp Sara M, Chiang Eddie T, Lassiter Quinea R, Lee Carmen, Phanse Shivani, Turnidge Megan A, Zhao Ping, Garcia Joe G N, Gokhale Vijay, Yang Danzhou, Hurley Laurence H
Abstract excerpt
The platelet-derived growth factor receptor β (PDGFR-β) signaling pathway is a validated and important target for the treatment of certain malignant and nonmalignant pathologies. We previously identified a G-quadruplex-forming nuclease hypersensitive element (NHE) in the human PDGFR-β promoter that putatively forms four overlapping G-quadruplexes. Therefore, we further investigated the structures and biological...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.