Article

Detect Genomic G-Quadruplexes in Living Animal Cells with a Tiny Artificial Protein Probe

2020-05-08

Abstract excerpt

<h4>ABSTRACT</h4> G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated in essential physiological processes and serve as important drug targets. The genome-wide detection of G4s in living cells is important for exploring the biological role of G4s but has not yet been achieved due to the lack of a suitable G4 probe. We engineered a 6.7 kDa G4 probe (G4P) protein that binds G4s with hig...

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Literature Corpus work: b275a1f3-da19-5da3-a743-de5889f971a5
DOI: 10.1101/2020.05.06.080622

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