Article
The Sherpa hypothesis: Phenotype-Preserving Disordered Proteins stabilize the phenotypes of neurons and oligodendrocytes.
NPJ systems biology and applications - 11 Jul 2023
Norris Vic, Oláh Judit, Krylov Sergey N, Uversky Vladimir N, Ovádi Judit
Abstract excerpt
Intrinsically disordered proteins (IDPs), which can interact with many partner proteins, are central to many physiological functions and to various pathologies that include neurodegeneration. Here, we introduce the Sherpa hypothesis, according to which a subset of stable IDPs that we term Phenotype-Preserving Disordered Proteins (PPDP) play a central role in protecting cell phenotypes from perturbations. To...
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