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G-quadruplex inducer/stabilizer pyridostatin targets <i>SUB1</i> to promote cytotoxicity of a transplatinum complex

20 Feb 2022

Abstract excerpt

Pyridostatin (PDS) is a well-known G-quadruplex (G4) inducer and stabilizer, yet its target genes have remained unclear. Herein, applying MS proteomics strategy, we revealed PDS significantly downregulated 22 proteins but upregulated 16 proteins in HeLa cancer cells, of which the genes both contain a number of G4 potential sequences, implying that PDS regulation on gene expression is far more complicated than...

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PMID: 35258624
DOI: 10.1093/nar/gkac151

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