Article

Evolution of subgenomic RNA shapes dengue virus adaptation and epidemiological fitness

2018-02-19

Abstract excerpt

Genetic changes in the dengue virus (DENV) genome affects viral fitness both clinically and epidemiologically. Even in the 3’ untranslated region (3’UTR), mutations could impact the formation of subgenomic flaviviral RNA (sfRNA) and the specificity of sfRNA in inhibiting host proteins necessary for successful viral replication. Indeed, we have recently shown that mutations in the 3’UTR of DENV2 affected its abilit...

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Literature Corpus work: 9254be37-51a7-5b9f-83b8-4e5f332fdb17
DOI: 10.1101/267922

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