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Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

3 Jul 2015

Abstract excerpt

The global spread of dengue virus (DENV) infections has increased viral genetic diversity, some of which appears associated with greater epidemic potential. The mechanisms governing viral fitness in epidemiological settings, however, remain poorly defined. We identified a determinant of fitness in a foreign dominant (PR-2B) DENV serotype 2 (DENV-2) clade, which emerged during the 1994 epidemic in Puerto Rico and...

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PMID: 26138103
DOI: 10.1126/science.aab3369

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