Article
Positive epistasis between viral polymerase and the 3' untranslated region of its genome reveals the epidemiologic fitness of dengue virus.
Proceedings of the National Academy of Sciences of the United States of America - 19 May 2020
Syenina Ayesa, Vijaykrishna Dhanasekaran, Gan Esther Shuyi, Tan Hwee Cheng, Choy Milly M, Siriphanitchakorn Tanamas, Cheng Colin, Vasudevan Subhash G, Ooi Eng Eong
Abstract excerpt
Dengue virus (DENV) is a global health threat, causing repeated epidemics throughout the tropical world. While low herd immunity levels to any one of the four antigenic types of DENV predispose populations to outbreaks, viral genetic determinants that confer greater fitness for epidemic spread is an important but poorly understood contributor of dengue outbreaks. Here we report that positive epistasis between the...
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