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Article

Dengue virus genomic variation associated with mosquito adaptation defines the pattern of viral non-coding RNAs and fitness in human cells.

PLoS pathogens - 1 Mar 2017

Filomatori Claudia V, Carballeda Juan M, Villordo Sergio M, Aguirre Sebastian, Pallarés Horacio M, Maestre Ana M, Sánchez-Vargas Irma, Blair Carol D, Fabri Cintia, Morales Maria A, Fernandez-Sesma Ana, Gamarnik Andrea V

Abstract excerpt

The Flavivirus genus includes a large number of medically relevant pathogens that cycle between humans and arthropods. This host alternation imposes a selective pressure on the viral population. Here, we found that dengue virus, the most important viral human pathogen transmitted by insects, evolved a mechanism to differentially regulate the production of viral non-coding RNAs in mosquitos and humans, with a...

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Identifiers

PMID: 28264033
DOI: 10.1371/journal.ppat.1006265
PMCID: PMC5354447

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