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Article

Subgenomic flavivirus RNA as key target for live-attenuated vaccine development

29 May 2024

Abstract excerpt

Live-attenuated flavivirus vaccines confer long-term protection against disease, but the design of attenuated flaviviruses does not follow a general approach. The non-coding, subgenomic flavivirus RNA (sfRNA) is produced by all flaviviruses and is an essential factor in viral pathogenesis and transmission. We argue that modulating sfRNA expression is a promising, universal strategy to finetune flavivirus...

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PMID: 38808973
DOI: 10.1128/jvi.00100-23

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