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Evolution of Subgenomic RNA Shapes Dengue Virus Adaptation and Epidemiological Fitness

16 May 2019

Abstract excerpt

Changes in dengue virus (DENV) genome affect viral fitness both clinically and epidemiologically. Even in the 3' untranslated region (3' UTR), mutations could affect subgenomic flaviviral RNA (sfRNA) production and its affinity for host proteins, which are necessary for successful viral replication. Indeed, we recently showed that mutations in DENV2 3' UTR of epidemic strains increased sfRNA ability to bind host...

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PMID: 31154208
DOI: 10.1016/j.isci.2019.05.019

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