Article

Inflammatory Cytokines Regulate T-Cell Development from Blood Progenitor Cells in a Stage and Dose-Specifc Manner

2021-01-19

Abstract excerpt

<h4>ABSTRACT</h4> T-cell development from hematopoietic stem and progenitor cells (HSPCs) is tightly regulated through Notch pathway activation by the Notch ligands Delta-like (DL) 1 and 4 and Jagged-2. Other molecules, such as stem cell factor (SCF), FMS-like tyrosine kinase 3 ligand (Flt3L) and interleukin (IL)-7, play a supportive role in regulating the survival, differentiation, and proliferation of developin...

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Literature Corpus work: 924efc67-bd79-53ad-81b5-26f7f2c11bbc
DOI: 10.1101/2021.01.18.427186

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