Article

Serum-free differentiation platform for the generation of B lymphocytes and natural killer cells from human CD34+ cord blood progenitors

2025-05-27

Abstract excerpt

<h4>Introduction</h4> Pre-clinical research on B and NK cell development relies on traditional murine stromal cell-based systems with reduced physiological relevance and clinical applicability. <h4>Methods</h4> A serum-free, fully humanized co-culture system utilizing human bone marrow-derived mesenchymal stromal cells (BM-MSCs) was developed to differentiate CB-CD34+ cells towards B and NK cell lineages. Differ...

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Literature Corpus work: 8639c310-be6d-57e1-b76e-acd2ee646ad2
DOI: 10.1101/2025.05.22.655473

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