Article

DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells

2021-11-27

Abstract excerpt

<h4>ABSTRACT</h4> T cells are key mediators of the adaptive immune response and show tremendous efficacy as cellular therapeutics. However, obtaining primary T cells from human donors is expensive and variable. Pluripotent stem cells (PSCs) have the potential to serve as a consistent and renewable source of T cells, but differentiating PSCs into hematopoietic progenitors with T cell potential remains a significan...

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Literature Corpus work: 1d0ca7c9-ed06-5bdb-b6fb-da8beec4fc39
DOI: 10.1101/2021.11.26.470145

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