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A stromal cell free culture system generates mouse pro‐T cells that can reconstitute T‐cell compartments in vivo

19 Nov 2014

Abstract excerpt

T-cell lymphopenia following BM transplantation or diseases such as AIDS result in immunodeficiency. Novel approaches to ameliorate this situation are urgently required. Herein, we describe a novel stromal cell free culture system in which Lineage(-) Sca1(+)c-kit(+) BM hematopoietic progenitors very efficiently differentiate into pro-T cells. This culture system consists of plate-bound Delta-like 4 Notch ligand...

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PMID: 25408420
DOI: 10.1002/eji.201444681

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