Article

Generation of effector CD4+ T cells from human iPSC

2025-08-02

Abstract excerpt

<h4>ABSTRACT</h4> Off the shelf CD4+ T cell therapies, particularly those with immunoregulatory or cell repair functions, could be transformative in CAR therapies for cancers and treatment of chronic inflammatory diseases. However, progress is stunted in this area due to challenges generating human CD4+ T cells from induced pluripotent stem cells. Here we describe a key role for the withdrawal of Notch ligand dur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 74c61ebd-a632-536c-be65-a9b41afd8efd
DOI: 10.1101/2025.08.01.667959

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Generation of effector CD4+ T cells from human iPSCDOI 10.1101/2025.08.01.667959Read

Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cellsSemantic proximity Read

Generation of CD34 <sup>+</sup> CD43 <sup>+</sup> hematopoietic progenitors to induce thymocytes from human pluripotent stem cellsSemantic proximity Read

A Serum- and Feeder-Free System to Generate CD4 and Regulatory T Cells from Human iPSCsSemantic proximity Read

A serum- and feeder-free system to generate CD4 and regulatory T cells from human iPSCsSemantic proximity Read

Combining the induced pluripotent stem cell (iPSC) technology with chimeric antigen receptor (CAR)-based immunotherapy: recent advances, challenges, and future prospectsSemantic proximity Read

Lineage tracing of T cell differentiation from T-iPSC by 2D feeder-free culture and 3D organoid cultureSemantic proximity Read

DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cellsSemantic proximity Read

Efficient Generation of Functional TCRαβ <sup>+</sup> Cytotoxic T Cells from hiPSCs via Small-Molecule ModulationSemantic proximity Read

CD29 marks superior cytotoxic human T cellsSemantic proximity Read

A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapySemantic proximity Read

Genome editing iPSC to purposing enhancement of induce CD8 killer T cell function for regenerative immunotherapySemantic proximity Read

Generation and clinical potential of functional T lymphocytes from gene-edited pluripotent stem cellsSemantic proximity Read