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The Development of T Cells From Stem Cells in Mice and Humans

16 Mar 2017

Abstract excerpt

T cells develop from hematopoietic stem cells in the specialized microenvironment of the thymus. The main transcriptional players of T-cell differentiation such as Notch, Tcf-1, Gata3 and Bcl11b have been identified, but their role and regulation are not yet completely understood. In humans, functional experiments on T-cell development have traditionally been rather difficult to perform, but novel in vitro...

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PMID: 28883990
DOI: 10.4155/fsoa-2016-0095

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