Article
Cord blood CD34+ cells cultured with FLT3L, stem cell factor, interleukin-6, and IL-3 produce CD11c+CD1a-/c- myeloid dendritic cells.
Stem cells and development - 1 Oct 2007
Fadilah S A W, Vuckovic S, Khalil D, Hart D N J
Abstract excerpt
Methods that allow expansion of myeloid dendritic cells (MDCs) from CD34(+) cells are potentially important for boosting anti-leukemic responses after cord blood (CB) hematopoietic stem cell transplantation (HSCT). We showed that the combination of early-acting cytokines FLT3-ligand (FL), stem cell factor (SCF), interleukin (IL)-3, and IL-6 supported the generation of CD11c(+)CD16() CD1a()/c() MDCs from CB...
Topics
- Antigens, CD1
- Antigens, CD34
- CD11c Antigen
- Cell Proliferation
- Cells, Cultured
- Dendritic Cells
- Fetal Blood
- Humans
- Interleukin-3
- Interleukin-6
- Interleukins
- Membrane Proteins
- Myeloid Cells
- Phenotype
- Stem Cell Factor
- Stem Cells
- T-Lymphocytes