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Article

Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.

BMC immunology - 16 Aug 2012

Patel Ekta S, Okada Starlyn, Hachey Kevin, Yang Li-jun, Durum Scott K, Moreb Jan S, Chang Lung-Ji

Abstract excerpt

BACKGROUND: The role of IL-7 and pre-TCR signaling during T cell development has been well characterized in murine but not in human system. We and others have reported that human BM hematopoietic progenitor cells (HPCs) display poor proliferation, inefficient double negative (DN) to double positive (DP) transition and no functional maturation in the in vitro OP9-Delta-like 1 (DL1) culture system. RESULTS: In this...

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Identifiers

PMID: 22897934
DOI: 10.1186/1471-2172-13-46
PMCID: PMC3496569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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