Article
Generation of dendritic cells from bone marrow progenitors using GM-CSF, TNF-alpha, and additional cytokines: antagonistic effects of IL-4 and IFN-gamma and selective involvement of TNF-alpha receptor-1.
Immunology - 1 Aug 1997
Lardon F, Snoeck H W, Berneman Z N, Van Tendeloo V F, Nijs G, Lenjou M, Henckaerts E, Boeckxtaens C J, Vandenabeele P, Kestens L L, Van Bockstaele D R, Vanham G L
Abstract excerpt
We report the generation of dendritic cells (DC) starting from CD34+ bone marrow (BM) progenitor cells, using a two-stage culture system in which, besides granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-alpha), stem-cell factor (SCF) was added during the first 5 days, while interleukin-4 (IL-4) and/or interferon-gamma (IFN-gamma) were added during the secondary...
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