Article

Carfilzomib Shows Therapeutic Potential for Reduction of Liver Fibrosis by Targeting Hepatic Stellate Cell Activation

2024-06-11

Abstract excerpt

<title>Abstract</title> <p>Because hepatic stellate cells (HSCs) play a major role in fibrosis, we focused on HSCs as a potential target for the treatment of liver fibrosis. In this study, we attempted to identify drug candidates to inactivate HSCs and found that several proteasome inhibitors (PIs) reduced HSC viability. Our data showed that a second-generation PI, carfilzomib (CZM), suppressed the expression of...

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Literature Corpus work: 924b0bce-7819-5f9d-9e5c-e597c81daea4
DOI: 10.21203/rs.3.rs-4453616/v1

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