Article

Discovery of 3,7-dimethoxyflavone that inhibits liver fibrosis based on dual mechanisms of antioxidant and inhibitor of activated hepatic stellate cell

2023-01-11

Abstract excerpt

<title>Abstract</title> <p>The important pathway toward liver fibrosis is the TGF-β1-induced activation of hepatic stellate cells (HSCs). To discover chemicals to inhibit liver fibrosis, we screened 3,000 chemicals using cell array system where human HSCs line LX2 cells are activated with TGF-β1. We discovered 3,7-dimethoxyflavone (3,7-DMF) as a chemical to inhibit TGF-β1-induced activation of HSCs. In the thioac...

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Literature Corpus work: 6b7aecdc-9a3e-5905-aef6-e15f2181139d
DOI: 10.21203/rs.3.rs-2232319/v1

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