Article

Survival and Proliferation of Activated Hepatic Stellate Cells Requires REST

2025-03-20

Abstract excerpt

<title>Abstract</title> <p> The activation of hepatic stellate cells (HSCs) is a key driver of liver fibrosis and inflammation in metabolic dysfunction-associated steatotic liver disease (MASLD). Targeting activated HSCs has shown promise in preventing liver fibrosis and cancer in mouse models. HSC activation is characterized by increased mitochondrial metabolism and upregulation of pro-fibrotic genes. Since RE1...

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Literature Corpus work: e99dbba6-0bb1-5e36-a7c5-aaf0bb750525
DOI: 10.21203/rs.3.rs-6237126/v1

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