Article

Targeting Hepatic Stellate Cells for the Prevention and Treatment of Liver Cirrhosis and Hepatocellular Carcinoma: Strategies and Clinical Translation

2025-02-24

Abstract excerpt

Hepatic stellate cells (HSC) are the major source of myofibroblasts (MFB) in fibrosis and cancer associated fibroblasts (CAF) in both primary and metastatic liver cancer. Over the past few decades, there has been significant progress in understanding the cellular and molecular mechanisms by which liver fibrosis and HCC occur and the key roles of HSC in the pathogenesis. HSC targeted approaches via specific surface...

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Literature Corpus work: ce5e8e93-317b-5ce1-a439-2cf303d5be78
DOI: 10.20944/preprints202502.1865.v1

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