Article

KLF4 Inhibits Activation of Human Hepatic Stellate Cells LX-2 in vitro

2021-09-07

Abstract excerpt

<title>Abstract</title> <p>BackgroundHepatic Stellate Cell (HSC) represents a key factor in liver fibrosis. Early-stage liver fibrosis is still reversible and is intimately associated with the state of HSC. KLF4 has been shown to play a pivotal role in a wide array of physiological and pathological processes. MethodsIn this study, we examined the effect of Kruppel-like factor 4 (KLF4) on the proliferation, apopto...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2eb2ba5b-c908-5c07-88b5-a695a2ae201d
DOI: 10.21203/rs.3.rs-702048/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

KLF4 Inhibits Activation of Human Hepatic Stellate Cells LX-2 in vitroDOI 10.21203/rs.3.rs-702048/v1Read

Regulatory long non‑coding RNAs of hepatic stellate cells in liver fibrosis (Review)Semantic proximity Read

Induction of premature senescence and a less-fibrogenic phenotype by programmed cell death 4 knockdown in the human hepatic stellate cell line Lieming Xu-2.Semantic proximity Read

Key Anti-Fibrosis Associated Long Noncoding RNAs Identified in Human Hepatic Stellate Cell via Transcriptome Sequencing Analysis.Semantic proximity Read

KLF6 alleviates hepatic ischemia-reperfusion injury by inhibiting autophagySemantic proximity Read

Targeting EIF5A improves liver fibrosis by inhibiting mitochondrial function of hepatic stellate cellsSemantic proximity Read

Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate CellsSemantic proximity Read

Molecular interplays in hepatic stellate cells: apoptosis, senescence, and phenotype reversion as cellular connections that modulate liver fibrosis.Semantic proximity Read

KLF6 transcription factor protects hepatocellular carcinoma-derived cells from apoptosis.Semantic proximity Read

Isolation and Characterization of AFP+/DLK1+ Double-Positive Hepatic Stem/Progenitor Cells from Fibrotic PHx ModelSemantic proximity Read

Mesoderm/mesenchyme homeobox l as a potential target that orchestrates hepatic stellate cell activationSemantic proximity Read

Hepatocyte nuclear factor 4α induces a tendency of differentiation and activation of rat hepatic stellate cells.Semantic proximity Read

Mesenchymal stem cells improve liver fibrosis and protect hepatocytes by promoting microRNA-148a-5p mediated inhibition of Notch signaling pathwaySemantic proximity Read